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دانشگاه علوم پزشکی ایران
Iran University of Medical Sciences


Triggers, Facilitators, and Aggravators: Redefining Parkinson’s Disease Pathogenesis

Michaela E.Johnson, Benjamin Stecher, Viviane Labrie, Lena Brundin, PatrikBrundin
https://doi.org/10.1016/j.tins.2018.09.007Get rights and content

Highlights
We propose a new conceptual model for PD pathogenesis, in which disease-associated factors are divided into three categories: triggers, facilitators, and aggravators.
Triggers are agents or events that begin the disease process; these factors are necessary but insufficient for PD to develop.
Facilitators are factors that allow the disease to spread to, and significantly impact, the central nervous system.
Aggravators directly promote the neurodegenerative process and often have a snowballing effect that exacerbates pathology and spreads the disease beyond the basal ganglia.
We propose that clinical therapies aimed at slowing or arresting PD progression should not only be given to patients enriched for the appropriate target (i.e., administered to the appropriate subpopulation), but also be applied during the appropriate temporal phase at which the relevant factor is most active.


A Pharmacology Primer
4th Edition
Techniques for More Effective and Strategic Drug Discovery
Authors: Terry Kenakin


Description
A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, 4th Edition features the latest ideas and research about the application of pharmacology to the process of drug discovery to equip readers with a deeper understanding of the complex and rapid changes in this field. Written by well-respected pharmacologist, Terry P. Kenakin, this primer is an indispensable resource for all those involved in drug discovery. This edition has been thoroughly revised to include material on data-driven drug discovery, biased signaling, structure-based drug design, drug activity screening, drug development (including pharmacokinetics and safety Pharmacology), and much more. With more color illustrations, examples, and exercises throughout, this book remains a top reference for all industry and academic scientists and students directly involved in drug discovery, or pharmacologic research.

Key Features
  • Highlights changes surrounding the strategy of drug discovery to provide you with a comprehensive reference featuring advances in the methods involved in lead optimization and more effective drug discovery
  • Includes a new chapter on data-driven drug discovery in terms of the optimal design of pharmacological experiments to identify mechanism of action of new molecules
  • Illustrates the application of rapid inexpensive assays to predict activity in the therapeutic setting, showing data outcomes and the limitations inherent in interpreting this data
 
 
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